Physiology / Other Methods
Blood and Oxygen Supply of Tissue
Oxygen supply of tissue
Comparison with alternative methods

Blood and Oxygen Supply of Tissue

Microcirculation is necessary for exchange of nutrients and oxygen.

O2C measures:

Oxygen supply of tissue

Oxygen Means Life

Oxygen is essential for almost all cells of biological tissue. Oxygen is mostly transported from the lungs to the capillaries bound to hemoglobin, which is located in erythrocytes. In the capillary network it is consumed by the cells.
Arterial hemoglobin in the greater cardiovascular system is saturated with oxygen up to almost 100% in the lungs (pulse oximeter measurement ). In peripheral tissues oxygen is distributed by the capillaries to the cells. Corresponding low saturation´s of hemoglobin with oxygen are measured in the tissue area at the end of capillaries, close to the venules and even less in the venules close to the veins.

Monitoring of Energetic Metabolism of Cells

With O2C , it is possible to measure locally the amount of oxygen which is transported into the region of interest and to diagnose local oxygen consumption of an organ.  's novelty is monitoring the energetic metabolism of cells by measuring the oxygen uptake with an optical sensor probe. Pathological O2-supply, which can lead to angiogenesis or cell-death and subsequently to organ failure, now can be detected in an early state by use of the new sensor system.

Monitoring of Oxygen Supply Simultaneously in Different Layers of Tissue

The O2C  is a multiple channel system which makes it possible to determine perfusion quantities and oxygen values. Channel 1 records the superficial oxygen saturation of hemoglobin (e.g. of the skin), while channel 2 monitors the oxygen supply and hemoglobin values of deeper tissue (e.g. skeletal muscle), due to the extended measurement volume.

Comparison with alternative methods

Global Oxygen Supply Parameter

Local Supply Parameter