Organ Transplantation
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Liver Transplants 
Kidney Transplants
Liver Transplants
A successful
organ transplantation depends on sufficient perfusion and oxygen supply after
reconnection of the vessels.
Measurements
of oxygen saturation and hemoglobin amount in the isolated perfused rat liver
show patterns of anatomical structures that represent the liver acini (Fig.
1 und 2). Changes in oxygen saturation and hemoglobin amount can now be observed.
With O2C you can only get averaged values over the whole area of the depicted
high resolution measurement, but those measurements reflect very good local
condition of liver and oxygen and blood supply during different manipulations
(occlusion of portal vein or liver artery, etc.).
[click on figure to maximize]
Figure
1: Oxygen saturation in an area of 2 x 2 mm of the surface of
a rat liver in high spatial resolution, that show anatomical structures
[click on figure to maximize]
Figure 2: Hemoglobin amount in 2 x 2 mm of the surface of a rat liver in spatial resolution, that reflect anatomical structures.
Literature:
O2C
Papers
- A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids, in early systemic inflammation.
C. Wunder, R. W. Brock, A. Krug, N. Roewer, O. Eichelbrönner; Comparative Hepatology 2005; 4:1 doi:10.1186/1476-5926-4-1
- O2C relevant data extracted from "A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids, in early systemic inflammation"
- Hypothermic oxygenation of the rat liver after cold storage prevents reperfusion injury
P. Dutkowski, F. Duenschede, S. Westermann, Th. Junginger, Klinik für Allgemein- und Abdominalchirurgie, Universität Mainz; A. Krug, LEA Medizintechnik Gießen
; 6th World Congress on TRAUMA 2004
- Reflectance
Spectrophotometry and Tissue Oxygenation in Experimental and Clinical Practice
M. P. Buise, J. van Bommel, C. Ince;
Yearbook of Intensive Care and Emergency Medicine 2003, Edited by J.-L. Vincent, Springer Verlag
- Detection
of mitochondrial electron chain carrier redox status by transhepatic
light intensity during rat liver reperfusion
P. Dutkowski, A. Krug, M. Krysiak, F. Dunschede, J. K. Seifert, T. Junginger;
Cryobiology. 2003 Oct
Habilitationen / Habilitations
Empho
Papers
Thesis
Kidney Transplants
Literature:
